Iinkcukacha zeMveliso

Iithegi zeMveliso

Uhlalutyo lwe-Pharmacological efficacy

i-pharmacological-efficacy-analysis-product

Uhlalutyo lwe-Pharmacological efficacy lubhekiselele kuvavanyo kunye novavanyo lwentsebenzo yamachiza ekufezekiseni iziphumo zabo zonyango ezijoliswe kuzo.Linyathelo elibalulekileyo kwinkqubo yophuhliso lwamachiza kwaye licacisa iinzuzo ezinokuthi zibe kho kunye nezithintelo kwikhompawundi yoxubo mayeza.

Ngohlalutyo lwe-pharmacological efficacy, abaphandi bajonge ukufumanisa ukuba ichiza lisebenzisana njani ne-receptor ekujoliswe kuyo okanye inkqubo yebhayoloji, ekhokelela kwimpendulo efunwayo ye-physiological.

I-MingCeler inokubonelela ngeemodeli ezahlukeneyo zempuku ezifanelekileyo ezinje ngobuntu kunye nokuguqulwa kofuzo ngokweemfuno zabathengi, ngakumbi imifuziselo yezifo ezihleliweyo ezinokulinganisa ngokuchanekileyo inkqubo yophuhliso lwezifo zabantu, ezinokuthi zisetyenziswe ukuvavanya nokuhlalutya ukusebenza kwamachiza kunye ukuphucula izinga lempumelelo yophuhliso lwamachiza amatsha.

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Uvavanyo lwesalathisi segazi se-biochemical

-In vitro knock-out okanye overexpression of target genenes in genetically engineered celllines

-In vivo knock-out okanye overexpression ye-target genes kwiimodeli zemouse

-In vivo ukuvavanya ukusebenza kuquka ukukhula ithumba, metastasis, njl.·

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Ukuziphatha kwezilwanyana

·Uvavanyo lwesakhono sokufunda kunye nenkumbulo:

I-maze yamanzi kaMorris (inkumbulo yokufunda yendawo, imemori yokusebenza, imemori yereferensi, ukufunda okuguqulweyo, imemori exhomekeke kwi-hippocampal);I-Barnes maze (ukufunda nokukhumbula indawo);

Uloyiko olunemiqathango:

Imemori yeemvakalelo, uloyiko oluxhomekeke kwi-hippocampal-exhomekeke kwi-associative, uloyiko olungaxhomekekanga kwi-hippocampal, imemori yexesha elide, imemori yesikhashana, imemori exhomekeke kwi-amygdala, kunye noloyiko lokuphendula.

·UVavanyo lokuZiphatha ngokuxhalaba:

Ukuphakama kwe-Cross Maze, uVavanyo lwe-Conditioned Fear, uVavanyo lokuZiphatha kwiNdawo yokungabikho, i-Startle Response, kunye ne-Social Interaction Behaviour.

·Uvavanyo lokuziphatha kuxinzelelo:

Umfuniselo omtsha we-hypophagia wendalo esingqongileyo, umfuniselo womsila ojingayo, ulingelo lokuqubha ngokunyanzeliswa, uvavanyo lokuziphatha ngokungahambi, uvavanyo lokuziphatha konxibelelwano loluntu, kunye nokufumana ukungabi nakuzinceda.

·Uvavanyo lokuziphatha olunxulumene neentlungu:

Umlinganiselo wentlungu ngepleyiti eshushu, umlinganiselo weentlungu ngokungcangcazela komsila (ubushushu be-infrared kunye noxinzelelo olubangelwe)

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Isalathiso

[1]Othman MZ,Hassan Z, Che Has AT.Imaze yamanzi kaMorris: isixhobo esisebenza ngeendlela ezininzi nesifanelekileyo sokuvavanya ukufunda kwendawo kunye nenkumbulo.Exp Anim.2022 Agasti 5; 71 (3): 264-280.doi:10.1538/expanim.21-0120.Epub 2022 Mar 18. PMID: 35314563;I-PMCID: PMC9388345.

Qhagamshelana nathi

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