Iinkcukacha zeMveliso

Iithegi zeMveliso

I-Quickmice™ ekhawulezayo ukwenza iMouse ye-CKO

I-Conditional Knock-out (CKO) yitekhnoloji ye-tissue ye-gene yokunkqonkqoza ephunyezwe yinkqubo yokuhlanganiswa kwendawo.

Olunye uncedo oluphambili lokunkqonkqozwa ngokwemiqathango kukukwazi ukufunda ukusebenza kwemfuza ngendlela elawulwa ngakumbi.Ngokukhetha ukungasebenzi kwezakhi zofuzo kwiindawo ezithile zexesha okanye kwizicubu ezithile, abaphandi banokujonga iziphumo zokulahleka kwemfuza kwaye bafumane ukuqonda kwiindlela ezisisiseko zeenkqubo ezahlukeneyo zebhayoloji.

Kuthatha ngaphezu kweenyanga ze-10-12 ukwakha imodeli ye-mouse ye-CKO enezinga eliphantsi lempumelelo usebenzisa inkqubo ye-Cre / LoxP yendabuko, njengoko le nkqubo idinga iigundane ze-Flox ukuba zidibanise nemouse kunye nokubonakaliswa okuthe ngqo kweCre.

Isizukulwana esitsha seTekhnoloji yokuLungiselela iMouse eKhawulezayo

I-TurboMice™

Singakunika ngokukhawuleza imifuziselo yemouse ye-CKO homozygous ngokusebenzisa ubuchwepheshe be-TurboMice™ ukuphucula izinga lempumelelo.

Ngokusekwe kweyona nkqubo ilungileyo yokuhlela imfuza ngoosonzululwazi bethu, sinokugqiba ukuhlolwa kweeseli ze-embryonic ezihleliweyo ngaphakathi kweentsuku ezi-3-5, emva koko sakhe i-tetraploid embryo.Emva kwe-surrogacy yomama, iigundane ze-homozygous humanized zingafumaneka kwiinyanga ezi-2-4, ezinokugcina iinyanga ezi-7-8 kubathengi.

Umxholo weNkonzo

Inombolo yenkonzo. Izalathisi zobugcisa Umxholo wokuhanjiswa Umjikelo wokuhanjiswa
MC003-1 ubude bejini elinye <5kb 3-9 CKO homozygous inkunzi iimpuku Iinyanga ezi-2-4
MC003-2 ubude bejini elinye <5kb 10-19 CKO homozygous inkunzi iimpuku Iinyanga ezi-2-4
MC003-3 ubude bejini elinye <5kb 20 CKO homozygous inkunzi iimpuku 3-5 iinyanga
MC003-4 ubude bejini enye yi-5kb-10kb 3-9 CKO homozygous inkunzi iimpuku 3-4 iinyanga
MC003-5 ubude bejini enye yi-5kb-10kb 10-19 CKO homozygous inkunzi iimpuku 3-4 iinyanga
MC003-6 ubude bejini enye yi-5kb-10kb 20 CKO homozygous inkunzi iimpuku 3-5 iinyanga

Qhagamshelana nathi

Nceda uqhagamshelane nathi ku:

1) Nceda ukhuphele kwaye ugcwalise le fomu ingezantsi《Ifomu yesicelo sekowuti》, kwaye uyithumele nge-imeyile kuMingCelerOversea@mingceler.com;

2) Umnxeba: +86 181 3873 9432;

3) LinkedIn:https://www.linkedin.com/company/ uthengar/

Ifomu yesicelo sekowuti.docx

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