Iseli kuthiwa i-homozygous kuhlobo oluthile lwemfuza xa ii-alleles ezifanayo zejini zikhoyo kuzo zombini iichromozomi ezinehomologous.
Imodeli yempuku ye-homozygous sisilwanyana saselebhu esiqhele ukusetyenziswa esiye sahlelwa ngokwemfuza ukuze sibe neekopi ezimbini ezifanayo zejini elithile.Le modeli isetyenziswa kakhulu kuphando lwezenzululwazi ukuphonononga izifo ezahlukeneyo zemfuza kunye nezifo.
Ngobuchwepheshe bendabuko, kuthatha ubuncinane izizukulwana ezi-2-3 zokuzala kunye nokuhlola ukufumana iigundane ze-homozygous ezivela kwiigundane ezixhasa ngemali, ezixabisa iinyanga ezili-10-12 ezinezinga eliphantsi lempumelelo.