Iinkcukacha zeMveliso

Iithegi zeMveliso

Quickmice™ Ukwenziwa ngokwezifiso kweMouse yeKI ngokukhawuleza

i-quickmice-fast-ki-mouse-customization-product

I-Knock-in (Knock-in, KI) bubuchule obusebenzisa ukudityaniswa kwakhona kwe-homologous yejini ukuhambisa i-exogenous yejini esebenzayo kulandelelwano lwe-homologous kwiseli kunye ne-genome, kwaye ufumane ukubonakaliswa kakuhle kwiseli emva kokuhlanganiswa kwakhona kwemfuza.

Kuthatha iinyanga ezi-5-6 ukufumana iimpuku ze-heterozygous ezicinyiweyo kunye neenyanga ezili-10-12 zizonke ukwakha imouse ye-KI homozygous enezinga eliphantsi lempumelelo kusetyenziswa ubuchule bemveli, kuba obu buchule bune-chimera ephantsi kwaye ifuna ukukhwelana ngempuku. Fumana iimpuku ze-heterozygous ezisusiweyo i-Neo, kwaye emva koko ukhulise iimpuku ze-heterozygous ezizelwe kwizizukulwana ezi-2-3 ukufumana iimpuku ze-KI homozygous.

Isizukulwana esitsha seTekhnoloji yokuLungiselela iMouse eKhawulezayo

I-TurboMice™

Singakunika ngokukhawuleza imifuziselo yeempuku ze-KI homozygous ngokusebenzisa ubuchwepheshe be-TurboMice™ ukuphucula izinga lempumelelo.

Ngokusekwe kweyona nkqubo ilungileyo yokuhlela imfuza ngoosonzululwazi bethu, sinokugqiba ukuhlolwa kweeseli ze-embryonic ezihleliweyo ngaphakathi kweentsuku ezi-3-5, emva koko sakhe i-tetraploid embryo.Emva kwe-surrogacy yomama, iigundane ze-homozygous humanized zingafumaneka kwiinyanga ezi-2-4, ezinokugcina iinyanga ezi-7-8 kubathengi.

Umxholo weNkonzo

Inombolo yenkonzo. Izalathisi zobugcisa Umxholo wokuhanjiswa Umjikelo wokuhanjiswa
MC002-1 ubude bejini elinye <5kb 3-9 KI homozygous iimpuku zamadoda Iinyanga ezi-2-4
MC002-2 ubude bejini elinye <5kb 10-19 KI homozygous inkunzi iimpuku Iinyanga ezi-2-4
MC002-3 ubude bejini elinye <5kb 20 KI homozygous iimpuku eziyindoda 3-5 iinyanga
MC002-4 ubude bejini enye yi-5kb-10kb 3-9 KI homozygous iimpuku zamadoda 3-4 iinyanga
MC002-5 ubude bejini enye yi-5kb-10kb 10-19 KI homozygous inkunzi iimpuku 3-4 iinyanga
MC002-6 ubude bejini enye yi-5kb-10kb 20 KI homozygous iimpuku eziyindoda 3-5 iinyanga

Qhagamshelana nathi

Nceda uqhagamshelane nathi ku:

1) Nceda ukhuphele kwaye ugcwalise le fomu ingezantsi《Ifomu yesicelo sekowuti》, kwaye uyithumele nge-imeyile kuMingCelerOversea@mingceler.com;

2) ITe: +86 181 3873 9432;

3) LinkedIn: https://www.linkedin.com/company/ uthengar/

Ifomu yesicelo sekowuti.docx

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